DHDDS

Across TCGA cell cohorts, DHDDS RNA expression is significantly associated with the go_rna of many other GO terms, with 3,690 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHDDS-associated GO terms across cancer lineages are COPI-coated vesicle budding, Golgi transport vesicle coating, and COPI coating of Golgi vesicle. Each is linked with DHDDS in more than 15 cancer types. Because this analysis shows association rather than direction, both DHDDS-to-partner and partner-to-DHDDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPI-coated vesicle budding grouped by DHDDS-low versus DHDDS-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDDS→partner) and Y-score (partner→DHDDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	COPI-coated vesicle budding →	+0.118	+0.869	<.001	<.001	3	16
SOFT_TISSUE	Golgi transport vesicle coating →	+0.118	+0.869	<.001	<.001	3	16
SOFT_TISSUE	COPI coating of Golgi vesicle →	+0.118	+0.869	<.001	<.001	3	16
LIVER	Endosomal transport →	+0.054	+0.934	<.001	.004	3	13
BONE	Negative regulation of cilium assembly →	+0.064	+0.660	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Caveolin-mediated endocytosis →	+0.216	+0.958	.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,690 associations by consensus.

COPI-coated vesicle budding by DHDDS expression — SOFT_TISSUE

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