DHDDS

Across TCGA cell cohorts, DHDDS mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DHDDS-associated genes across cancer lineages are LRRC3C, PPP1R2C, and CST8. Each is linked with DHDDS in more than 1 cancer types. Because this analysis shows association rather than direction, both DHDDS-to-partner and partner-to-DHDDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRRC3C grouped by DHDDS-low versus DHDDS-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DHDDS→partner) and Y-score (partner→DHDDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LRRC3C →	+0.352	+3.777	<.001	.007	3	1
BLOOD_Leukemia	PPP1R2C →	+0.307	+5.539	<.001	.003	3	1
BLOOD_Leukemia	CST8 →	+0.062	+5.969	<.001	.001	3	1
BLOOD_Leukemia	NKX2-6 →	+0.663	+5.201	<.001	.006	3	1
BLOOD_Leukemia	KRTAP21-2 →	+0.085	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM24A →	+0.082	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

LRRC3C by DHDDS expression — LARGE_INTESTINE

Explore this box plot interactively →