DHCR7

Across TCGA pan-cancer cohorts, DHCR7 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DHCR7 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DHCR7 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DHCR7 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where DHCR7 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	II,III,IV	0.800	0.308	.001	18	view →
CCRCC	OS	Tertile	All	0.525	0.974	.011	8	view →
PDAC	DFS	Tertile	III,IV	0.551	0.166	.036	8	view →
HNSC	OS	Quartile	IV	0.599	0.850	.034	2	view →
LUAD	DFS	Quartile	All	0.671	0.843	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DHCR7–LSCC (DFS)

Open the LSCC breakdown →