DGUOK

Across TCGA patient cohorts, DGUOK mutation is significantly associated with the RNA expression of many other genes, with 635 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGUOK-associated genes across cancer lineages are RNU6-1067P, EIF3JP1, and MIR6803. Each is linked with DGUOK in more than 1 cancer types. Because this analysis shows association rather than direction, both DGUOK-to-partner and partner-to-DGUOK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1067P grouped by DGUOK-low versus DGUOK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGUOK→partner) and Y-score (partner→DGUOK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1067P →	+0.324	+2.605	<.001	.003	3	2
UCEC	EIF3JP1 →	+0.189	+2.690	<.001	.001	3	2
UCEC	MIR6803 →	+0.279	+5.603	<.001	<.001	3	2
UCEC	MIR4445 →	+0.231	+4.893	<.001	.001	3	2
COAD	ATF1P1 →	+0.228	+6.392	.003	.001	3	1
COAD	H3P9 →	+0.429	+5.602	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 635 associations by consensus.

RNU6-1067P by DGUOK expression — UCEC

Explore this box plot interactively →