DGUOK

Across TCGA patient cohorts, DGUOK mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGUOK-associated genes across cancer lineages are FOXO3a_pS318_S321, JNK_pT183_Y185, and MEK1. Each is linked with DGUOK in more than 1 cancer types. Because this analysis shows association rather than direction, both DGUOK-to-partner and partner-to-DGUOK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a_pS318_S321 grouped by DGUOK-low versus DGUOK-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGUOK→partner) and Y-score (partner→DGUOK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a_pS318_S321 →	-0.132	-2.990	.043	.036	3	1
UCEC	JNK_pT183_Y185 →	-0.209	-3.308	.017	.010	3	1
UCEC	MEK1 →	+0.459	+3.321	.016	.010	3	1
UCEC	ARID1A →	-0.284	-3.314	.002	.010	3	1
UCEC	STAT3_pY705 →	-0.502	-3.321	<.001	.010	3	1
UCEC	Stathmin →	+0.142	+3.000	.048	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

FOXO3a_pS318_S321 by DGUOK expression — UCEC

Explore this box plot interactively →