DGKZ

Across TCGA patient cohorts, DGKZ protein abundance is significantly associated with the RNA expression of many other genes, with 9,017 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DGKZ-associated genes across cancer lineages are ABCD2, CD6, and KLHL6. Each is linked with DGKZ in more than 5 cancer types. Because this analysis shows association rather than direction, both DGKZ-to-partner and partner-to-DGKZ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DGKZ versus ABCD2 in GBM, with a Pearson correlation of 0.56.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKZ→partner) and Y-score (partner→DGKZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ABCD2 →	+0.886	+0.373	<.001	<.001	3	6
BRCA	CD6 →	+0.731	+0.249	.002	.001	3	5
UCEC	KLHL6 →	+1.171	+0.213	<.001	.001	3	5
UCEC	CORO1A →	+0.955	+0.191	.005	.002	3	4
BRCA	CD48 →	+1.124	+0.320	<.001	<.001	3	4
BRCA	PSTPIP1 →	+0.856	+0.297	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,017 associations by consensus.

DGKZ vs ABCD2 — GBM

Explore this scatter interactively →