DGKZ

Across TCGA patient cohorts, DGKZ mutation is significantly associated with the RNA expression of many other genes, with 2,591 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKZ-associated genes across cancer lineages are SAAL1, DCTN6, and TLE6. Each is linked with DGKZ in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKZ-to-partner and partner-to-DGKZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAAL1 grouped by DGKZ-low versus DGKZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKZ→partner) and Y-score (partner→DGKZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SAAL1 →	+0.362	+1.737	.008	.002	3	3
UCEC	DCTN6 →	+0.368	+2.330	.006	.003	3	3
UCEC	TLE6 →	+0.523	+1.737	.009	.002	3	3
UCEC	NAPG →	+0.326	+2.254	.005	.005	3	3
GBM	MIR5583-1 →	+0.823	+7.209	<.001	<.001	3	2
HNSC	HMGB1P13 →	+0.112	+4.624	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,591 associations by consensus.

SAAL1 by DGKZ expression — UCEC

Explore this box plot interactively →