DGKZ

Across TCGA patient cohorts, DGKZ mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKZ-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and MSH6. Each is linked with DGKZ in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKZ-to-partner and partner-to-DGKZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DGKZ-low versus DGKZ-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKZ→partner) and Y-score (partner→DGKZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.850	+3.321	.007	.009	3	3
COAD	ASNS →	+0.342	+3.000	.033	.034	3	3
UCEC	MSH6 →	-0.435	-2.459	<.001	.018	3	2
UCEC	ATM →	-0.548	-2.687	<.001	.005	3	2
UCEC	eIF4E →	+0.229	+3.000	.003	<.001	3	1
UCEC	ERK2 →	+0.225	+2.906	.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Caspase-7-cleavedD198 by DGKZ expression — COAD

Explore this box plot interactively →