DGKZ

Across TCGA cell cohorts, DGKZ RNA expression is significantly associated with the go_rna of many other GO terms, with 4,159 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGKZ-associated GO terms across cancer lineages are Regulation of metaphase plate congression, Meiotic chromosome condensation, and Negative regulation of t-circle formation. Each is linked with DGKZ in more than 11 cancer types. Because this analysis shows association rather than direction, both DGKZ-to-partner and partner-to-DGKZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of metaphase plate congression grouped by DGKZ-low versus DGKZ-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKZ→partner) and Y-score (partner→DGKZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of metaphase plate congression →	+0.149	+0.801	<.001	<.001	3	12
SOFT_TISSUE	Meiotic chromosome condensation →	+0.188	+1.199	<.001	<.001	3	12
BONE	Negative regulation of t-circle formation →	+0.165	+1.057	<.001	<.001	3	12
BONE	Signal transduction in response to DNA damage →	+0.084	+0.977	<.001	<.001	3	12
BONE	Positive regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.149	+0.864	<.001	<.001	3	12
LARGE_INTESTINE	Erythrocyte maturation →	+0.069	+0.647	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,159 associations by consensus.

Regulation of metaphase plate congression by DGKZ expression — SKIN

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