DGKZ

Across TCGA cell cohorts, DGKZ mutation is significantly associated with the RNA expression of many other genes, with 338 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGKZ-associated genes across cancer lineages are FMR1NB, ASB17, and GUCA1C. Each is linked with DGKZ in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKZ-to-partner and partner-to-DGKZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FMR1NB grouped by DGKZ-low versus DGKZ-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKZ→partner) and Y-score (partner→DGKZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FMR1NB →	+0.889	+3.847	.008	.006	3	2
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	2
URINARY_TRACT	GUCA1C →	+0.341	+3.584	.004	.009	3	1
URINARY_TRACT	DAZ1 →	+0.118	+3.584	.009	.009	3	1
UPPER_AERODIGESTIVE_TRACT	FAM236A →	+0.120	+5.357	<.001	.003	3	1
BLOOD_Lymphoma	IRGC →	+0.026	+3.502	.004	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 338 associations by consensus.

FMR1NB by DGKZ expression — CNS

Explore this box plot interactively →