DGKK

Across TCGA pan-cancer cohorts, DGKK Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated DGKK data layer compared with 23 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DGKK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DGKK expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KIRP, UCEC, and UVM are the cancer types where DGKK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	DFS	Median	All	0.040	0.912	<.001	36	view →
UCEC	DFS	Median	II,III,IV	0.883	0.423	.007	26	view →
UVM	OS	Median	All	0.220	0.917	<.001	18	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	15	view →
DLBC	OS	Median	All	0.054	0.842	<.001	12	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
PRAD	DFS	Median	All	0.110	0.776	<.001	6	view →
ACC	DFS	Median	All	0.089	0.666	.017	6	view →
SARC	OS	Median	All	0.238	0.826	.001	3	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

DGKK–KIRP (DFS)

Open the KIRP breakdown →