DGKH

Across TCGA patient cohorts, DGKH mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKH-associated genes across cancer lineages are Rictor_pT1135, 14-3-3_beta, and FoxM1. Each is linked with DGKH in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKH-to-partner and partner-to-DGKH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rictor_pT1135 grouped by DGKH-low versus DGKH-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKH→partner) and Y-score (partner→DGKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Rictor_pT1135 →	-0.164	-3.000	.039	.036	3	3
UCEC	14-3-3_beta →	-0.085	-2.195	.008	.009	3	2
UCEC	FoxM1 →	+0.190	+1.777	.021	.002	3	2
UCEC	HER2_pY1248 →	-0.174	-2.058	.041	<.001	3	2
UCEC	Notch1 →	+0.145	+1.424	.001	.027	3	2
UCEC	S6_pS240_S244 →	+0.302	+3.000	.019	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Rictor_pT1135 by DGKH expression — STAD

Explore this box plot interactively →