DGKH

Across TCGA cell cohorts, DGKH mutation is significantly associated with the RNA expression of many other genes, with 50 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGKH-associated genes across cancer lineages are OTC, DEFB132, and ZNF735. Each is linked with DGKH in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKH-to-partner and partner-to-DGKH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OTC grouped by DGKH-low versus DGKH-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKH→partner) and Y-score (partner→DGKH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OTC →	+0.062	+2.681	<.001	.008	3	2
CNS	DEFB132 →	+0.324	+4.321	<.001	.009	3	2
SOFT_TISSUE	ZNF735 →	+0.206	+5.369	<.001	.004	3	1
BLOOD_Leukemia	PHOX2B →	+0.013	+3.365	.003	.005	3	1
BLOOD_Leukemia	TREH →	+0.018	+2.979	<.001	.007	3	1
BLOOD_Leukemia	TTR →	+0.176	+3.968	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 50 associations by consensus.

OTC by DGKH expression — BLOOD_Leukemia

Explore this box plot interactively →