DGKE

Across TCGA patient cohorts, DGKE mutation is significantly associated with the RNA expression of many other genes, with 3,552 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKE-associated genes across cancer lineages are RNU6-113P, TRDJ2, and SNRPCP20. Each is linked with DGKE in more than 2 cancer types. Because this analysis shows association rather than direction, both DGKE-to-partner and partner-to-DGKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-113P grouped by DGKE-low versus DGKE-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKE→partner) and Y-score (partner→DGKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU6-113P →	+0.408	+7.930	<.001	.008	3	3
COAD	TRDJ2 →	+1.359	+4.384	<.001	.006	3	3
COAD	SNRPCP20 →	+0.633	+4.831	<.001	.003	3	3
UCEC	SAMM50 →	+0.447	+3.823	.003	<.001	3	2
UCEC	TRMU →	+0.541	+2.736	<.001	<.001	3	2
UCEC	NUP93 →	+0.463	+2.258	.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,552 associations by consensus.

RNU6-113P by DGKE expression — LUAD

Explore this box plot interactively →