DGKE

Across TCGA patient cohorts, DGKE mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGKE-associated genes across cancer lineages are JNK_pT183_Y185, p70-S6K_pT389, and EGFR_pY1068. Each is linked with DGKE in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKE-to-partner and partner-to-DGKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by DGKE-low versus DGKE-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKE→partner) and Y-score (partner→DGKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.247	-3.074	<.001	<.001	3	2
UCEC	p70-S6K_pT389 →	-0.169	-2.459	.027	.018	3	2
UCEC	EGFR_pY1068 →	-0.241	-2.584	.017	.010	3	1
UCEC	eIF4E →	+0.169	+1.906	.046	.016	3	1
UCEC	eIF4G →	+0.259	+2.415	.038	.003	3	1
UCEC	ACC1 →	+0.311	+2.820	.033	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

JNK_pT183_Y185 by DGKE expression — UCEC

Explore this box plot interactively →