DGKE

Across TCGA cell cohorts, DGKE RNA expression is significantly associated with the go_rna of many other GO terms, with 4,288 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGKE-associated GO terms across cancer lineages are Microtubule organizing center organization, Regulation of microtubule-based process, and Microtubule polymerization. Each is linked with DGKE in more than 11 cancer types. Because this analysis shows association rather than direction, both DGKE-to-partner and partner-to-DGKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Microtubule organizing center organization grouped by DGKE-low versus DGKE-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKE→partner) and Y-score (partner→DGKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Microtubule organizing center organization →	+0.076	+0.867	<.001	.005	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of microtubule-based process →	+0.055	+0.940	<.001	<.001	3	12
LIVER	Microtubule polymerization →	+0.121	+1.440	<.001	.001	3	11
BONE	Centrosome cycle →	+0.085	+1.170	<.001	<.001	3	11
SOFT_TISSUE	Termination of RNA polymerase II transcription →	+0.108	+0.899	<.001	<.001	3	11
LARGE_INTESTINE	mRNA splice site recognition →	+0.123	+0.952	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,288 associations by consensus.

Microtubule organizing center organization by DGKE expression — LUNG_SCLC

Explore this box plot interactively →