DGKE

Across TCGA cell cohorts, DGKE mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DGKE-associated genes across cancer lineages are GAGE12E, PRMT8, and TLX3. Each is linked with DGKE in more than 1 cancer types. Because this analysis shows association rather than direction, both DGKE-to-partner and partner-to-DGKE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAGE12E grouped by DGKE-low versus DGKE-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGKE→partner) and Y-score (partner→DGKE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	GAGE12E →	+0.076	+4.643	<.001	.008	3	1
BLOOD_Leukemia	PRMT8 →	+0.573	+4.409	<.001	.005	3	1
LARGE_INTESTINE	TLX3 →	+0.462	+3.845	.001	.003	3	1
UPPER_AERODIGESTIVE_TRACT	CCL18 →	+0.031	+3.510	<.001	.007	3	1
CNS	HES3 →	+0.041	+5.321	<.001	.005	3	1
BLOOD_Lymphoma	RPE65 →	+0.010	+4.350	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

GAGE12E by DGKE expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →