DGCR8

Across TCGA pan-cancer cohorts, DGCR8 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DGCR8 data layer compared with 25 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DGCR8 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DGCR8 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where DGCR8 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	III,IV	0.762	0.958	.011	13	view →
HNSC	OS	Median	III,IV	0.846	0.575	.020	9	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →
LUAD	OS	Median	All	0.563	0.857	.012	8	view →
GBM	DFS	Tertile	All	0.582	0.280	.011	4	view →
LSCC	DFS	Quartile	All	0.859	0.206	.002	4	view →
UCEC	DFS	Quartile	All	1.000	0.894	.041	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DGCR8–CCRCC (DFS)

Open the CCRCC breakdown →