DGCR8

Across TCGA patient cohorts, DGCR8 protein abundance is significantly associated with the RNA expression of many other genes, with 24,209 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DGCR8-associated genes across cancer lineages are MTFR2, CDCA5, and MCM10. Each is linked with DGCR8 in more than 8 cancer types. Because this analysis shows association rather than direction, both DGCR8-to-partner and partner-to-DGCR8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DGCR8 versus MTFR2 in OV, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR8→partner) and Y-score (partner→DGCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MTFR2 →	+0.869	+0.438	.002	<.001	3	9
LUAD	CDCA5 →	+0.914	+0.256	<.001	<.001	3	9
LUAD	MCM10 →	+1.034	+0.251	<.001	<.001	3	9
BRCA	MYBL2 →	+1.941	+0.288	<.001	<.001	3	8
UCEC	CEP55 →	+0.910	+0.141	<.001	<.001	3	8
OV	SPC25 →	+1.320	+0.460	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 24,209 associations by consensus.

DGCR8 vs MTFR2 — OV

Explore this scatter interactively →