DGCR8

Across TCGA patient cohorts, DGCR8 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGCR8-associated genes across cancer lineages are ATM, Lck, and Fibronectin. Each is linked with DGCR8 in more than 2 cancer types. Because this analysis shows association rather than direction, both DGCR8-to-partner and partner-to-DGCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DGCR8-low versus DGCR8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR8→partner) and Y-score (partner→DGCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.549	-2.489	<.001	.001	3	3
COAD	Lck →	+0.455	+2.832	.006	.035	3	3
UCEC	Fibronectin →	-0.213	-1.382	.035	.017	3	2
UCEC	JNK2 →	+0.200	+1.263	.001	.019	3	2
UCEC	MEK1 →	+0.372	+2.070	<.001	.001	3	2
UCEC	mTOR_pS2448 →	-0.094	-1.893	.038	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

ATM by DGCR8 expression — UCEC

Explore this box plot interactively →