DGCR8

Across TCGA cell cohorts, DGCR8 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,204 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DGCR8-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Transcription elongation-coupled chromatin remodeling. Each is linked with DGCR8 in more than 19 cancer types. Because this analysis shows association rather than direction, both DGCR8-to-partner and partner-to-DGCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by DGCR8-low versus DGCR8-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR8→partner) and Y-score (partner→DGCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Symbiont-mediated disruption of host cellular anatomical structure →	+0.180	+0.988	<.001	.001	3	20
BREAST	Symbiont-mediated disruption of host anatomical structure →	+0.180	+0.988	<.001	.001	3	20
BONE	Transcription elongation-coupled chromatin remodeling →	+0.130	+1.421	<.001	<.001	3	18
BONE	Regulation of transcription of nucleolar large rRNA by RNA polymerase I →	+0.151	+1.075	<.001	<.001	3	18
BONE	Epigenetic regulation of gene expression →	+0.083	+1.258	<.001	<.001	3	18
SOFT_TISSUE	Microtubule polymerization →	+0.111	+1.138	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,204 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by DGCR8 expression — BREAST

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