DGCR8

Across TCGA cell cohorts, DGCR8 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DGCR8-associated genes across cancer lineages are GGT2, FAM71E2, and LRRTM3. Each is linked with DGCR8 in more than 1 cancer types. Because this analysis shows association rather than direction, both DGCR8-to-partner and partner-to-DGCR8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GGT2 grouped by DGCR8-low versus DGCR8-high in BONE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR8→partner) and Y-score (partner→DGCR8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	GGT2 →	+0.214	+4.307	<.001	.004	3	1
BONE	FAM71E2 →	+0.018	+4.672	.003	.001	3	1
BLOOD_Leukemia	LRRTM3 →	+0.004	+4.539	<.001	.007	3	1
BLOOD_Lymphoma	C18orf63 →	+0.012	+4.867	<.001	.009	3	1
SKIN	PRB4 →	+0.046	+4.684	<.001	.002	3	1
LARGE_INTESTINE	LRRC3C →	+0.395	+3.777	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GGT2 by DGCR8 expression — BONE

Explore this box plot interactively →