DGCR5

Across TCGA patient cohorts, DGCR5 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,163 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DGCR5-associated GO terms across cancer lineages are Regulation of axonogenesis, Negative regulation of axonogenesis, and Regulation of extent of cell growth. Each is linked with DGCR5 in more than 18 cancer types. Because this analysis shows association rather than direction, both DGCR5-to-partner and partner-to-DGCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of axonogenesis grouped by DGCR5-low versus DGCR5-high in TGCT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR5→partner) and Y-score (partner→DGCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	Regulation of axonogenesis →	+0.044	+0.729	<.001	<.001	3	19
TGCT	Negative regulation of axonogenesis →	+0.061	+0.646	<.001	<.001	2	19
STAD	Regulation of extent of cell growth →	+0.047	+0.274	<.001	<.001	3	18
STAD	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process →	+0.043	+0.191	<.001	<.001	3	17
STAD	Neuron projection organization →	+0.035	+0.218	<.001	<.001	3	17
STAD	Neuron projection extension →	+0.048	+0.320	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,163 associations by consensus.

Regulation of axonogenesis by DGCR5 expression — TGCT

Explore this box plot interactively →