DGCR5

Across TCGA patient cohorts, DGCR5 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGCR5-associated genes across cancer lineages are EGFR_pY1068, Gab2, and MEK1. Each is linked with DGCR5 in more than 1 cancer types. Because this analysis shows association rather than direction, both DGCR5-to-partner and partner-to-DGCR5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by DGCR5-low versus DGCR5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR5→partner) and Y-score (partner→DGCR5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.262	-2.700	.020	.006	3	1
UCEC	Gab2 →	+0.475	+2.999	.003	.035	3	1
UCEC	MEK1 →	+0.336	+2.000	.041	.032	3	1
UCEC	Notch1 →	+0.206	+2.331	.001	.019	3	1
UCEC	PCNA →	+0.255	+2.000	.008	.032	3	1
UCEC	PDCD4 →	-0.750	-2.449	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

EGFR_pY1068 by DGCR5 expression — UCEC

Explore this box plot interactively →