DGCR2

Across TCGA pan-cancer cohorts, DGCR2 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DGCR2 data layer compared with 23 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher DGCR2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DGCR2 expression acts as an unfavorable survival marker.

LUSC, GBM, and CESC are the cancer types where DGCR2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.043	0.819	<.001	15	view →
GBM	OS	Median	All	0.058	0.416	<.001	12	view →
CESC	OS	Median	II,III,IV	0.203	0.759	.021	6	view →
SKCM	DFS	Median	II,III,IV	0.376	0.576	.022	4	view →
SARC	DFS	Median	All	0.109	0.632	.038	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DGCR2–LUSC (OS)

Open the LUSC breakdown →