DGCR2

Across TCGA pan-cancer cohorts, DGCR2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DGCR2 data layer compared with 23 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DGCR2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DGCR2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

LUAD, PDAC, and GBM are the cancer types where DGCR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	II,III,IV	0.310	0.868	.003	12	view →
PDAC	DFS	Median	II,III,IV	0.442	0.260	.020	10	view →
GBM	OS	Quartile	All	0.602	0.921	.012	9	view →
UCEC	DFS	Median	All	1.000	0.889	.025	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DGCR2–LUAD (OS)

Open the LUAD breakdown →