DGCR2

Across TCGA cell cohorts, DGCR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,244 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DGCR2-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cellular anatomical structure, Symbiont-mediated disruption of host anatomical structure, and Vacuolar transport. Each is linked with DGCR2 in more than 18 cancer types. Because this analysis shows association rather than direction, both DGCR2-to-partner and partner-to-DGCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cellular anatomical structure grouped by DGCR2-low versus DGCR2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR2→partner) and Y-score (partner→DGCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Symbiont-mediated disruption of host cellular anatomical structure →	+0.166	+1.212	<.001	.003	3	19
KIDNEY	Symbiont-mediated disruption of host anatomical structure →	+0.166	+1.212	<.001	.003	3	19
UPPER_AERODIGESTIVE_TRACT	Vacuolar transport →	+0.057	+0.906	.002	.001	3	16
KIDNEY	Positive regulation of macrophage proliferation →	+0.228	+1.122	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to nucleus →	+0.077	+0.996	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.063	+0.648	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,244 associations by consensus.

Symbiont-mediated disruption of host cellular anatomical structure by DGCR2 expression — KIDNEY

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