DGCR2

Across TCGA cell cohorts, DGCR2 mutation is significantly associated with the RNA expression of many other genes, with 573 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGCR2-associated genes across cancer lineages are CRYBB1, EPO, and HSF5. Each is linked with DGCR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DGCR2-to-partner and partner-to-DGCR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYBB1 grouped by DGCR2-low versus DGCR2-high in LIVER.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGCR2→partner) and Y-score (partner→DGCR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CRYBB1 →	+0.078	+3.977	.002	.006	3	2
LARGE_INTESTINE	EPO →	+0.132	+3.064	<.001	.009	3	2
LARGE_INTESTINE	HSF5 →	+0.025	+2.584	.003	.002	3	2
LARGE_INTESTINE	SMIM33 →	+0.406	+2.577	.004	.007	3	2
LUNG_NSCLC_LUAD	OR10D3 →	+0.086	+3.544	<.001	.009	3	2
SKIN	DAZ2 →	+0.585	+3.707	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 573 associations by consensus.

CRYBB1 by DGCR2 expression — LIVER

Explore this box plot interactively →