DGAT2

Across TCGA patient cohorts, DGAT2 mutation is significantly associated with the RNA expression of many other genes, with 984 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGAT2-associated genes across cancer lineages are MIR615, RNU6-648P, and RNU4-70P. Each is linked with DGAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DGAT2-to-partner and partner-to-DGAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR615 grouped by DGAT2-low versus DGAT2-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGAT2→partner) and Y-score (partner→DGAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR615 →	+0.458	+4.279	<.001	.003	3	2
LUSC	RNU6-648P →	+0.444	+6.751	<.001	<.001	3	2
BRCA	RNU4-70P →	+0.613	+8.055	<.001	.007	3	2
UCEC	PYCR1 →	+0.902	+2.847	<.001	.001	3	2
UCEC	FANCA →	+0.664	+3.721	<.001	<.001	3	2
UCEC	VDAC1 →	+0.490	+2.716	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 984 associations by consensus.

MIR615 by DGAT2 expression — LUSC

Explore this box plot interactively →