DGAT2

Across TCGA patient cohorts, DGAT2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DGAT2-associated genes across cancer lineages are eEF2, A-Raf_pS299, and FOXO3a_pS318_S321. Each is linked with DGAT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DGAT2-to-partner and partner-to-DGAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by DGAT2-low versus DGAT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGAT2→partner) and Y-score (partner→DGAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.395	+1.807	.007	.027	3	1
UCEC	A-Raf_pS299 →	-0.160	-1.807	.001	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.136	-1.807	.008	.027	3	1
UCEC	GAPDH →	+0.565	+2.459	.010	.019	3	1
UCEC	GATA6 →	-0.137	-2.985	.032	.034	3	1
UCEC	ACC1 →	+0.330	+2.183	.028	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

eEF2 by DGAT2 expression — UCEC

Explore this box plot interactively →