DGAT2

Across TCGA cell cohorts, DGAT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,660 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DGAT2-associated GO terms across cancer lineages are Diacylglycerol biosynthetic process, Fatty acid homeostasis, and Regulation of lipoprotein metabolic process. Each is linked with DGAT2 in more than 12 cancer types. Because this analysis shows association rather than direction, both DGAT2-to-partner and partner-to-DGAT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Diacylglycerol biosynthetic process grouped by DGAT2-low versus DGAT2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DGAT2→partner) and Y-score (partner→DGAT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Diacylglycerol biosynthetic process →	+0.153	+1.962	<.001	<.001	3	13
STOMACH	Fatty acid homeostasis →	+0.148	+1.465	<.001	<.001	3	10
PANCREAS	Regulation of lipoprotein metabolic process →	+0.101	+1.709	.002	.001	3	10
LARGE_INTESTINE	Intracellular triglyceride homeostasis →	+0.107	+1.550	<.001	<.001	3	8
LIVER	Diacylglycerol metabolic process →	+0.113	+2.683	.001	<.001	3	8
STOMACH	Neutral lipid biosynthetic process →	+0.092	+1.468	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,660 associations by consensus.

Diacylglycerol biosynthetic process by DGAT2 expression — LUNG_NSCLC_LUSC

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