Across TCGA pan-cancer cohorts, DGAT1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DGAT1 data layer compared with 26 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher DGAT1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DGAT1 expression acts as an unfavorable survival marker.

KIRC, SARC, and SKCM are the cancer types where DGAT1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.249	0.805	.010	12	view →
SARC	OS	Median	All	0.085	0.839	<.001	12	view →
SKCM	DFS	Median	All	0.202	0.760	<.001	9	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: DGAT1 tumor-vs-normal RNA expression · all DGAT1 data types