Across TCGA cell cohorts, DGAT1 mutation is significantly associated with the drug of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DGAT1-associated genes across cancer lineages are Pevonedistat, GSK2801, and Bromosporine. Each is linked with DGAT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DGAT1-to-partner and partner-to-DGAT1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DGAT1→partner) and Y-score (partner→DGAT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Pevonedistat →	+0.740	+2.649	.031	.046	3	1
LARGE_INTESTINE	GSK2801 →	+0.318	+2.649	.046	.046	3	1
LARGE_INTESTINE	Bromosporine →	+0.357	+2.649	.038	.046	3	1
LARGE_INTESTINE	SGC-CBP30 →	+0.318	+2.649	.024	.046	3	1
LARGE_INTESTINE	WZ4003 →	+0.415	+2.769	.046	.040	3	1
LARGE_INTESTINE	JAK1_8709 →	+0.470	+2.649	.016	.046	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

DGAT1 survival (RNA) · tumor vs normal (RNA) · all DGAT1 data types