DFFB

Across TCGA patient cohorts, DFFB mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DFFB-associated genes across cancer lineages are mTOR_pS2448, EGFR_pY1068, and ERK2. Each is linked with DFFB in more than 1 cancer types. Because this analysis shows association rather than direction, both DFFB-to-partner and partner-to-DFFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DFFB-low versus DFFB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DFFB→partner) and Y-score (partner→DFFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.139	-2.439	.023	.019	3	2
UCEC	EGFR_pY1068 →	-0.302	-2.321	.003	.006	3	1
UCEC	ERK2 →	+0.214	+3.169	.007	.018	3	1
UCEC	FoxM1 →	+0.257	+2.321	.016	.006	3	1
UCEC	GAPDH →	+0.571	+3.169	.009	.018	3	1
UCEC	JNK2 →	+0.247	+3.196	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

mTOR_pS2448 by DFFB expression — UCEC

Explore this box plot interactively →