DFFB

Across TCGA cell cohorts, DFFB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,759 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DFFB-associated GO terms across cancer lineages are Regulation of telomerase RNA localization to Cajal body, Regulation of T cell proliferation, and Regulation of lymphocyte proliferation. Each is linked with DFFB in more than 12 cancer types. Because this analysis shows association rather than direction, both DFFB-to-partner and partner-to-DFFB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of telomerase RNA localization to Cajal body grouped by DFFB-low versus DFFB-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DFFB→partner) and Y-score (partner→DFFB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of telomerase RNA localization to Cajal body →	+0.131	+0.965	.001	.002	3	13
BONE	Regulation of T cell proliferation →	-0.133	-1.010	<.001	<.001	3	12
BONE	Regulation of lymphocyte proliferation →	-0.085	-0.976	<.001	<.001	3	11
PANCREAS	Apoptotic DNA fragmentation →	+0.099	+0.656	<.001	<.001	2	12
BONE	Mitochondrial RNA metabolic process →	+0.102	+0.811	.001	<.001	3	11
BREAST	Endothelial to hematopoietic transition →	+0.073	+0.484	.005	.008	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,759 associations by consensus.

Regulation of telomerase RNA localization to Cajal body by DFFB expression — BONE

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