DET1

Across TCGA patient cohorts, DET1 protein abundance is significantly associated with the RNA expression of many other genes, with 1,094 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DET1-associated genes across cancer lineages are SUN2, RASL10A, and NEFH. Each is linked with DET1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DET1-to-partner and partner-to-DET1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DET1 versus SUN2 in GBM, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DET1→partner) and Y-score (partner→DET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SUN2 →	+0.991	+0.460	.009	.004	3	1
GBM	RASL10A →	+1.282	+0.460	.006	.004	3	1
GBM	NEFH →	+2.316	+0.460	.001	.004	3	1
GBM	SYNGR1 →	+1.693	+0.460	.009	.004	3	1
GBM	RANGAP1 →	+1.550	+0.599	.009	.009	3	1
GBM	CHGA →	+3.546	+0.460	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,094 associations by consensus.

DET1 vs SUN2 — GBM

Explore this scatter interactively →