DET1

Across TCGA patient cohorts, DET1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DET1-associated genes across cancer lineages are Cyclin-B1, ERK2, and PCNA. Each is linked with DET1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DET1-to-partner and partner-to-DET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by DET1-low versus DET1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DET1→partner) and Y-score (partner→DET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-B1 →	+0.651	+2.815	.029	.036	2	3
UCEC	ERK2 →	+0.190	+2.169	.002	.003	3	2
UCEC	PCNA →	+0.144	+1.392	.042	.019	3	2
UCEC	TFRC →	+0.372	+2.584	.033	.010	3	2
UCEC	14-3-3_beta →	-0.093	-2.780	.005	.003	3	1
UCEC	EGFR_pY1068 →	-0.206	-2.584	.012	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Cyclin-B1 by DET1 expression — COAD

Explore this box plot interactively →