DET1

Across TCGA cell cohorts, DET1 mutation is significantly associated with the RNA expression of many other genes, with 78 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DET1-associated genes across cancer lineages are C16orf92, NPHS2, and FUT5. Each is linked with DET1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DET1-to-partner and partner-to-DET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C16orf92 grouped by DET1-low versus DET1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DET1→partner) and Y-score (partner→DET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C16orf92 →	+0.154	+3.037	<.001	.001	3	2
URINARY_TRACT	NPHS2 →	+0.150	+4.044	.001	.001	3	1
URINARY_TRACT	FUT5 →	+0.130	+4.050	<.001	.002	3	1
URINARY_TRACT	LRFN5 →	+1.107	+3.584	<.001	.009	3	1
URINARY_TRACT	LOXHD1 →	+0.045	+3.584	.003	.009	3	1
URINARY_TRACT	RNASE8 →	+0.036	+3.584	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

C16orf92 by DET1 expression — BLOOD_Leukemia

Explore this box plot interactively →