DET1

Across TCGA cell cohorts, DET1 mutation is significantly associated with the mutation status of many other genes, with 4,537 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DET1-associated genes across cancer lineages are NOTCH3, SLC9A1, and HERC5. Each is linked with DET1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DET1-to-partner and partner-to-DET1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOTCH3 grouped by DET1-low versus DET1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DET1→partner) and Y-score (partner→DET1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NOTCH3 →	+2.498	+4.044	<.001	<.001	1	4
SKIN	SLC9A1 →	+5.053	+4.239	.007	.007	1	4
LUNG_NSCLC_LUAD	HERC5 →	+5.772	+5.772	.002	.002	1	4
UPPER_AERODIGESTIVE_TRACT	GABRB3 →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	PEAK1 →	+4.392	+4.954	.008	.008	1	4
UPPER_AERODIGESTIVE_TRACT	TRPM1 →	+4.392	+4.954	.008	.008	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,537 associations by consensus.

NOTCH3 by DET1 expression — BLOOD_Leukemia

Explore this box plot interactively →