DESI2

Across TCGA pan-cancer cohorts, DESI2 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DESI2 data layer compared with 28 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DESI2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DESI2 expression acts as an unfavorable survival marker.

LUAD, UCEC, and ESCA are the cancer types where DESI2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.223	0.788	.002	21	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
ESCA	OS	Median	II,III,IV	0.345	0.686	.047	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DESI2–LUAD (OS)

Open the LUAD breakdown →