DESI2

Across TCGA pan-cancer cohorts, DESI2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DESI2 data layer compared with 28 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher DESI2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DESI2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

LSCC, HNSC, and LUAD are the cancer types where DESI2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	III,IV	0.294	0.979	<.001	31	view →
HNSC	DFS	Median	All	0.860	0.361	.022	10	view →
LUAD	OS	Median	All	0.874	0.598	.011	9	view →
UCEC	OS	Median	II,III,IV	0.609	1.000	.008	8	view →
GBM	DFS	Tertile	All	0.865	0.459	.015	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DESI2–LSCC (DFS)

Open the LSCC breakdown →