DESI2

Across TCGA patient cohorts, DESI2 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DESI2-associated genes across cancer lineages are ATM, Ku80, and p70-S6K_pT389. Each is linked with DESI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DESI2-to-partner and partner-to-DESI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DESI2-low versus DESI2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DESI2→partner) and Y-score (partner→DESI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.453	-2.700	.013	.006	3	2
UCEC	Ku80 →	+0.194	+1.498	.041	.036	3	1
UCEC	p70-S6K_pT389 →	-0.155	-3.169	.042	.018	3	1
UCEC	PDCD4 →	-0.427	-2.312	.024	.034	3	1
UCEC	Tuberin →	+0.238	+1.884	.028	.030	3	1
UCEC	Chk2_pT68 →	-0.151	-2.312	.044	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

ATM by DESI2 expression — UCEC

Explore this box plot interactively →