DESI2

Across TCGA cell cohorts, DESI2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,289 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DESI2-associated GO terms across cancer lineages are Nuclear pore organization, Negative regulation of transcription by RNA polymerase I, and Establishment of protein localization to endoplasmic reticulum membrane. Each is linked with DESI2 in more than 18 cancer types. Because this analysis shows association rather than direction, both DESI2-to-partner and partner-to-DESI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear pore organization grouped by DESI2-low versus DESI2-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DESI2→partner) and Y-score (partner→DESI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Nuclear pore organization →	+0.127	+0.860	<.001	<.001	3	19
LUNG_NSCLC_LUSC	Negative regulation of transcription by RNA polymerase I →	+0.120	+0.745	.002	.003	3	15
OVARY	Establishment of protein localization to endoplasmic reticulum membrane →	+0.115	+0.964	<.001	<.001	3	14
OVARY	Transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery →	+0.127	+0.729	<.001	.001	3	14
OVARY	Nuclear pore complex assembly →	+0.126	+0.850	<.001	<.001	3	14
STOMACH	Regulation of endoplasmic reticulum tubular network organization →	+0.090	+0.587	.009	.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,289 associations by consensus.

Nuclear pore organization by DESI2 expression — SOFT_TISSUE

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