DERL3

Across TCGA pan-cancer cohorts, DERL3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DERL3 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DERL3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DERL3 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

HNSC, LUAD, and UCEC are the cancer types where DERL3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Quartile	All	0.883	0.583	.009	17	view →
LUAD	OS	Median	II,III,IV	0.862	1.000	.004	7	view →
UCEC	DFS	Median	All	0.605	1.000	.014	4	view →
LSCC	DFS	Quartile	III,IV	0.493	0.901	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DERL3–HNSC (DFS)

Open the HNSC breakdown →