DERL3

Across TCGA patient cohorts, DERL3 mutation is significantly associated with the RNA expression of many other genes, with 121 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DERL3-associated genes across cancer lineages are RNU5A-3P, MIR449B, and RNA5SP419. Each is linked with DERL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DERL3-to-partner and partner-to-DERL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU5A-3P grouped by DERL3-low versus DERL3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERL3→partner) and Y-score (partner→DERL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU5A-3P →	+0.486	+5.080	.008	.008	3	2
HNSC	MIR449B →	+0.323	+7.954	<.001	.008	3	2
UCEC	RNA5SP419 →	+1.331	+3.661	<.001	<.001	3	2
UCEC	RNA5SP422 →	+1.500	+3.893	<.001	<.001	3	2
CESC	PIEZO1P2 →	+0.014	+3.646	.007	.001	3	1
CESC	RN7SL62P →	+0.134	+4.397	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 121 associations by consensus.

RNU5A-3P by DERL3 expression — COAD

Explore this box plot interactively →