DERL3

Across TCGA patient cohorts, DERL3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DERL3-associated genes across cancer lineages are STAT3_pY705, cIAP, and Cyclin-B1. Each is linked with DERL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DERL3-to-partner and partner-to-DERL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by DERL3-low versus DERL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERL3→partner) and Y-score (partner→DERL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.491	-3.000	.001	.037	3	1
UCEC	cIAP →	+0.159	+3.026	.045	.019	2	1
UCEC	Cyclin-B1 →	+0.725	+3.000	.025	.037	2	1
UCEC	Notch1 →	+0.227	+3.000	.005	.037	1	1
UCEC	p62 Lck ligand →	+0.617	+3.000	.001	.037	1	1
UCEC	Caspase-8 →	-0.354	-3.000	.014	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

STAT3_pY705 by DERL3 expression — UCEC

Explore this box plot interactively →