DERL1

Across TCGA patient cohorts, DERL1 mutation is significantly associated with the RNA expression of many other genes, with 1,421 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DERL1-associated genes across cancer lineages are TRDV3, LIN7C, and INTS4. Each is linked with DERL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DERL1-to-partner and partner-to-DERL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRDV3 grouped by DERL1-low versus DERL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERL1→partner) and Y-score (partner→DERL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRDV3 →	+0.370	+2.161	<.001	.001	3	2
UCEC	LIN7C →	+0.550	+2.708	.004	.003	3	1
UCEC	INTS4 →	+0.374	+3.609	.002	.001	3	1
UCEC	AASDHPPT →	+0.524	+3.332	.006	.005	3	1
UCEC	GLB1L2 →	-0.931	-3.087	<.001	<.001	3	1
UCEC	LAMTOR1 →	+0.346	+3.354	.007	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,421 associations by consensus.

TRDV3 by DERL1 expression — UCEC

Explore this box plot interactively →