DERA

Across TCGA patient cohorts, DERA mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DERA-associated genes across cancer lineages are INPP4B, ATM, and Caspase-7-cleavedD198. Each is linked with DERA in more than 1 cancer types. Because this analysis shows association rather than direction, both DERA-to-partner and partner-to-DERA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by DERA-low versus DERA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERA→partner) and Y-score (partner→DERA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.361	-3.321	.010	.009	3	2
UCEC	ATM →	-0.716	-3.906	<.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.601	+3.189	.020	.010	3	2
UCEC	JNK2 →	+0.205	+2.807	.018	.003	3	1
UCEC	MEK1 →	+0.404	+3.321	.011	.010	3	1
UCEC	mTOR_pS2448 →	-0.135	-3.156	.038	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

INPP4B by DERA expression — UCEC

Explore this box plot interactively →