DERA

Across TCGA cell cohorts, DERA RNA expression is significantly associated with the go_rna of many other GO terms, with 2,404 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible DERA-associated GO terms across cancer lineages are 2'-deoxyribonucleoside metabolic process, Pentose-phosphate shunt, and NADPH regeneration. Each is linked with DERA in more than 9 cancer types. Because this analysis shows association rather than direction, both DERA-to-partner and partner-to-DERA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 2'-deoxyribonucleoside metabolic process grouped by DERA-low versus DERA-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DERA→partner) and Y-score (partner→DERA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	2'-deoxyribonucleoside metabolic process →	+0.147	+0.741	.007	.008	3	10
BREAST	Pentose-phosphate shunt →	+0.142	+1.019	<.001	<.001	3	10
BREAST	NADPH regeneration →	+0.127	+0.979	<.001	<.001	3	9
BREAST	Nucleoside catabolic process →	+0.152	+0.915	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of DNA damage checkpoint →	+0.100	+0.812	<.001	.001	3	8
BREAST	2'-deoxyribonucleoside catabolic process →	+0.232	+0.891	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,404 associations by consensus.

2'-deoxyribonucleoside metabolic process by DERA expression — LUNG_SCLC

Explore this box plot interactively →