DERA

Across TCGA cell cohorts, DERA mutation is significantly associated with the RNA expression of many other genes, with 20 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DERA-associated genes across cancer lineages are CGB2, HAND1, and OR11H1. Each is linked with DERA in more than 1 cancer types. Because this analysis shows association rather than direction, both DERA-to-partner and partner-to-DERA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CGB2 grouped by DERA-low versus DERA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DERA→partner) and Y-score (partner→DERA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CGB2 →	+1.136	+4.234	<.001	.003	3	1
BLOOD_Leukemia	HAND1 →	+0.026	+4.408	<.001	.001	3	1
BLOOD_Leukemia	OR11H1 →	+0.063	+4.786	<.001	<.001	3	1
BLOOD_Leukemia	SLCO1C1 →	+0.076	+3.705	<.001	.007	3	1
BLOOD_Leukemia	GABRA6 →	+0.309	+3.855	<.001	.007	3	1
BLOOD_Leukemia	G6PC2 →	+0.200	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

CGB2 by DERA expression — BLOOD_Leukemia

Explore this box plot interactively →